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The purpose of this study was to analysis of histopathological profile of brain in hypertensive rats (DOCA- Salt) treated to Mistletoe (Tea and Mango) extract combination for 14 days. Samples were obtained using true experimental design with completely randomized on 25 rats with 3 treatments (TI, TII, TIII), control (-) and control (+) with replication 5 times. Ratio of extract for treatment was 3 : 1 namely 50 mg/KgBW, 100 mg/KgBW, 200 mg/KgBW. Data analysis using one-way analysis of variance (ANOVA) with the JAMOVI application. The results of the study obtained Mistletoe (Tea and Mango) extract combination in hypertensive rats (DOCA-Salt) can reduce the amount of necrosis of brain cells in the white matter area, significantly. The combination of Mistletoe extract can reduce the number of brain cell necrosis in hypertensive rats optimally obtained at a dose of 50 mg / KgBW
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